![]() ![]() ![]() (GC-MS) and flame ionization detection (GC-FID) determine the levels 5 However, further modification is needed to update (DNPH), 1 and GC-MS derivatization of DNPH. ![]() Methods of formaldehyde have been developed betweenĢ0, including the DLLME-LC UV–vis method, 4 high-performance liquid chromatography-diodeĪrray detector (HPLC-DAD) derivatization of 2,4-dinitrophenylhydrazine This method should have the characteristics for identifyingĪnd quantitatively determining the levels of formaldehyde releasedįrom the preservatives used in cream cosmetics. These products using the latest, sensitive, and validated analytical ![]() 3 Therefore, to meet the safety, efficacy, and quality requirementsįor cosmetics, notably formaldehyde releasers, it is crucial to analyze On Cancer (IARC) in 2006, formaldehyde was classified into group IĪs a human carcinogen based on evidence that formaldehyde substanceĬan cause nasopharyngeal cancer and myeloid leukemia. 2 According to the International Agency for Research Potentially cause allergies (allergens) when used in excess. Used in cleansing and skincare cosmetics products, they also might 1 However, despite these components being commonly Urea (IU) are the most widely used preservatives in cosmetics. Requirements for a validated analytical method and could be appliedįormaldehyde releasers such as diazolidinyl (for PTS liquid by GC-FID), respectively. Interval 95.0–105.0%, a limit of detection and quantitation The validated method showed intradayĪnd interday precision, an accuracy (% RSD) of less than 3.7%, confidence (DNPH) method with high-performance liquid chromatography (HPLC) toĬompare the quantification results. In addition, sample analysis was also carried out using the 2,4-dinitrophenylhydrazine Time and temperature of the reaction to yield the highest peak area. Of p-toluenesulfonic (PTS) acid in ethanol (acidifiedĮthanol), used as the derivatization agent, and the conditions of Modifications involved optimizations of five series of concentrations Therefore, this study aimed toĭevelop a new method using gas chromatography-mass spectrometry (GC-MS)Īnd gas chromatography-flame ionization detection (GC-FID). The problems involved in the standard method is that of obtainingĪ derivatization agent, especially for routine analysis in the NationalĪgency of Drug and Food, Indonesia. Have developed various methods for determining formaldehyde. However, formaldehyde releaser substancesĪre still widely used as a preservative in cosmetics. Formaldehyde has been reported to be a potential humanĬarcinogen due to its toxicity. ![]()
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January 2023
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